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2000 1
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52 results

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Page 1
The role of FHL2 in wound healing and inflammation.
Wixler V. Wixler V. FASEB J. 2019 Jul;33(7):7799-7809. doi: 10.1096/fj.201802765RR. Epub 2019 Apr 2. FASEB J. 2019. PMID: 30939249 Review.
Indeed, challenging FHL2-KO cells or mice provided numerous evidences for the great functional significance of FHL2. In recent years, several reviews have been published describing the high capacity of FHL2 to bind diverse proteins as well as the versatile fu …
Indeed, challenging FHL2-KO cells or mice provided numerous evidences for the great functional significance of FHL2. In recent …
Protein-protein interactions of the LIM-only protein FHL2 and functional implication of the interactions relevant in cardiovascular disease.
Tran MK, Kurakula K, Koenis DS, de Vries CJ. Tran MK, et al. Biochim Biophys Acta. 2016 Feb;1863(2):219-28. doi: 10.1016/j.bbamcr.2015.11.002. Epub 2015 Nov 6. Biochim Biophys Acta. 2016. PMID: 26548523 Free article. Review.
FHL2 belongs to the LIM-domain only proteins and contains four and a half LIM domains, each of which are composed of two zinc finger structures. ...FHL2 was originally identified in the heart and there is extensive literature available on the role of FHL2 in …
FHL2 belongs to the LIM-domain only proteins and contains four and a half LIM domains, each of which are composed of two zinc finger …
Glucose-mediated insulin secretion is improved in FHL2-deficient mice and elevated FHL2 expression in humans is associated with type 2 diabetes.
Habibe JJ, Clemente-Olivo MP, Scheithauer TPM, Rampanelli E, Herrema H, Vos M, Mieremet A, Nieuwdorp M, van Raalte DH, Eringa EC, de Vries CJM. Habibe JJ, et al. Diabetologia. 2022 Oct;65(10):1721-1733. doi: 10.1007/s00125-022-05750-1. Epub 2022 Jul 8. Diabetologia. 2022. PMID: 35802167 Free PMC article.
AIMS/HYPOTHESIS: The general population is ageing, involving an enhanced incidence of chronic diseases such as type 2 diabetes. With ageing, DNA methylation of FHL2 increases, as well as expression of the four and a half LIM domains 2 (FHL2) protein in human …
AIMS/HYPOTHESIS: The general population is ageing, involving an enhanced incidence of chronic diseases such as type 2 diabetes. With …
FHL2 expression and variants in hypertrophic cardiomyopathy.
Friedrich FW, Reischmann S, Schwalm A, Unger A, Ramanujam D, Münch J, Müller OJ, Hengstenberg C, Galve E, Charron P, Linke WA, Engelhardt S, Patten M, Richard P, van der Velden J, Eschenhagen T, Isnard R, Carrier L. Friedrich FW, et al. Basic Res Cardiol. 2014;109(6):451. doi: 10.1007/s00395-014-0451-8. Epub 2014 Oct 31. Basic Res Cardiol. 2014. PMID: 25358972 Free PMC article.
Based on evidence that FHL2 (four and a half LIM domains protein 2) negatively regulates cardiac hypertrophy we tested whether FHL2 altered expression or variants could be associated with hypertrophic cardiomyopathy (HCM). ...These data suggest that (1) FHL2 …
Based on evidence that FHL2 (four and a half LIM domains protein 2) negatively regulates cardiac hypertrophy we tested whether FHL …
FHL2 mediates podocyte Rac1 activation and foot process effacement in hypertensive nephropathy.
Li SY, Chu PH, Huang PH, Hsieh TH, Susztak K, Tarng DC. Li SY, et al. Sci Rep. 2019 Apr 30;9(1):6693. doi: 10.1038/s41598-019-42328-1. Sci Rep. 2019. PMID: 31040292 Free PMC article.
Here, we used micro-dissected human kidney samples, in vitro podocyte culture experiments, and a hypertension animal model to determine the possible role of FHL2 in hypertensive nephropathy. FHL2 was abundantly upregulated in hypertensive human glomeruli and animal …
Here, we used micro-dissected human kidney samples, in vitro podocyte culture experiments, and a hypertension animal model to determine the …
LIM-only protein FHL2 attenuates vascular tissue factor activity, inhibits thrombus formation in mice and FHL2 genetic variation associates with human venous thrombosis.
Kroone C, Vos M, Rademakers T, Kuijpers M, Hoogenboezem M, van Buul J, Heemskerk JWM, Ruf W, van Hylckama Vlieg A, Versteeg HH, Goumans MJ, de Vries CJM, Kurakula K; INVENT Consortium. Kroone C, et al. Haematologica. 2020 Jun;105(6):1677-1685. doi: 10.3324/haematol.2018.203026. Epub 2019 Aug 29. Haematologica. 2020. PMID: 31467128 Free PMC article.
Furthermore, we observed that FHL2 interacts with the cytoplasmic tail of TF. In line with our in vivo observations, FHL2 decreases TF activity in endothelial and smooth muscle cells whereas FHL2 knockdown or deficiency results in enhanced TF activity. ...Alt …
Furthermore, we observed that FHL2 interacts with the cytoplasmic tail of TF. In line with our in vivo observations, FHL2 decr …
How (Epi)Genetic Regulation of the LIM-Domain Protein FHL2 Impacts Multifactorial Disease.
Habibe JJ, Clemente-Olivo MP, de Vries CJ. Habibe JJ, et al. Cells. 2021 Oct 1;10(10):2611. doi: 10.3390/cells10102611. Cells. 2021. PMID: 34685595 Free PMC article. Review.
Four and a half LIM domains 2 (FHL2) is a key regulator of intracellular signal transduction pathways and the FHL2 gene is consistently found as one of the top hyper-methylated genes upon aging. ...In this review, we provide an overview of the current knowledge on r …
Four and a half LIM domains 2 (FHL2) is a key regulator of intracellular signal transduction pathways and the FHL2 gene is con …
The novel roles of four and a half LIM proteins 1 and 2 in the cardiovascular system.
Chu PH, Chen J. Chu PH, et al. Chang Gung Med J. 2011 Mar-Apr;34(2):127-34. Chang Gung Med J. 2011. PMID: 21539754 Free article. Review.
Four and a half LIM domains protein 1 (FHL1) and FHL2, as the name suggests, contain four and a half LIM domain binding proteins. ...This article reviews recent advances in the characterization of FHL1 and FHL2, their biological roles, LIM domain binding proteins, a …
Four and a half LIM domains protein 1 (FHL1) and FHL2, as the name suggests, contain four and a half LIM domain binding proteins. ... …
Screening and identification of a novel FHL2 mutation by whole exome sequencing in twins with familial Waldenstrom macroglobulinemia.
Wan Y, Cheng Y, Liu Y, Shen L, Hou J. Wan Y, et al. Cancer. 2021 Jun 15;127(12):2039-2048. doi: 10.1002/cncr.33454. Epub 2021 Mar 25. Cancer. 2021. PMID: 33764527 Free article.
RESULTS: Among the 10 shared candidate mutations in the twins, the authors identified a novel heterozygous germline mutation in four and a half LIM domains protein 2 (FHL2; c.G226A, p.V76M) as a familial WM-associated mutation. FHL2 appeared to be connected with rep …
RESULTS: Among the 10 shared candidate mutations in the twins, the authors identified a novel heterozygous germline mutation in four and a h …
FHL2, UBC9, and PIAS1 are novel estrogen receptor alpha-interacting proteins.
Kobayashi S, Shibata H, Yokota K, Suda N, Murai A, Kurihara I, Saito I, Saruta T. Kobayashi S, et al. Endocr Res. 2004 Nov;30(4):617-21. doi: 10.1081/erc-200043789. Endocr Res. 2004. PMID: 15666801
Estrogen plays important roles in the pathophysiology of atherosclerosis and cardiovascular diseases mediated by estrogen receptor alpha (ERalpha). ...Since tissue distribution of FHL2 was highly restricted to the heart, the function of FHL2 may be obs …
Estrogen plays important roles in the pathophysiology of atherosclerosis and cardiovascular diseases mediated by estrogen rece …
52 results